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Persistent Humoral Immunodeficiency with Rising Herpesvirus Loads Despite Successful IL-6 Blockade in a Patient with Idiopathic Multicentric Castleman Disease and IgM-λ Monoclonal Gammopathy

2026-07-08

Abstract excerpt

<title>Abstract</title> <p>Idiopathic multicentric Castleman disease (iMCD) typically presents with polyclonal hypergammaglobulinemia. We report a 25-year-old male with a 20-year history of generalized lymphadenopathy, found to have profoundly decreased serum IgG and IgA, markedly elevated IgM-λ monoclonal protein, and concurrent EBV, CMV, and HSV reactivation. Lymph node biopsy confirmed iMCD; bone marrow biopsy...

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Literature Corpus work: 800102c3-492a-5222-8f55-f1cc8bf22090
DOI: 10.21203/rs.3.rs-10122651/v1

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