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Spatial and single cell mapping of castleman disease reveals key stromal cell types and cytokine pathways

1 Jul 2025

Abstract excerpt

To determine the cellular and molecular basis of Castleman Disease (CD), we analyze the spatial proteome and transcriptome from a discovery (n = 9 cases) and validation (n = 13 cases) cohort of Unicentric CD, idiopathic Multicentric CD, HHV8-associated MCD, and reactive lymph nodes. CD shows increased stromal cells that form unique microenvironments. Interaction of activated follicular dendritic cell (FDC)...

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PMID: 40593805
DOI: 10.1038/s41467-025-61214-1

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