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Making Home Sweet and Sturdy:<i>Toxoplasma gondii</i>ppGalNAc-Ts Glycosylate in Hierarchical Order and Confer Cyst Wall Rigidity

11 Jan 2017

Abstract excerpt

The protozoan intracellular parasite Toxoplasma gondii forms latent cysts in the central nervous system (CNS) and persists for the lifetime of the host. This cyst is cloaked with a glycosylated structure called the cyst wall. Previously, we demonstrated that a mucin-like glycoprotein, CST1, localizes to the cyst wall and confers structural rigidity on brain cysts in a mucin-like domain-dependent manner. The...

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PMID: 28074022
DOI: 10.1128/mbio.02048-16

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