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Article

Molecular Signals in the Trafficking of <i>Toxoplasma gondii</i> Protein MIC3 to the Micronemes

5 Apr 2008

Abstract excerpt

The protozoan parasite Toxoplasma gondii is equipped with a sophisticated secretory apparatus, including three distinct exocytic organelles, named micronemes, rhoptries, and dense granules. We have dissected the requirements for targeting the microneme protein MIC3, a key component of T. gondii infection. We have shown that MIC3 is processed in a post-Golgi compartment and that the MIC3 propeptide and epidermal...

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Identifiers

PMID: 18390648
DOI: 10.1128/ec.00413-07

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Research trail→

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Molecular Signals in the Trafficking of <i>Toxoplasma gondii</i> Protein MIC3 to the MicronemesPMID 18390648Read ↗

A cathepsin C-like protease post-translationally modifies <i>Toxoplasma gondii</i> secretory proteins for optimal invasion and egressSemantic proximity Read ↗

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The Toxoplasma gondii protein MIC3 requires pro‐peptide cleavage and dimerization to function as adhesinSemantic proximity Read ↗

The lectin-specific activity of <i>Toxoplasma gondii</i> microneme proteins 1 and 4 binds Toll-like receptor 2 and 4 N-glycans to regulate innate immune primingSemantic proximity Read ↗

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Functional Characterization of 11 Tentative Microneme Proteins in Type I RH Strain of Toxoplasma gondii Using the CRISPR-Cas9 SystemSemantic proximity Read ↗

A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by <i>Toxoplasma</i>Semantic proximity Read ↗

Signaling Cascades Governing Entry into and Exit from Host Cells by Toxoplasma gondiiSemantic proximity Read ↗

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Secretory organelle trafficking in Toxoplasma gondii: A long story for a short travelSemantic proximity Read ↗

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