Back to search

Article

A cathepsin C-like protease post-translationally modifies <i>Toxoplasma gondii</i> secretory proteins for optimal invasion and egress

2023-01-22

Abstract excerpt

<h4>ABSTRACT</h4> Microbial pathogens use proteases for their infections, such as digestion of proteins for nutrients and activation of their virulence factors. As an obligate intracellular parasite, Toxoplasma gondii must invade host cells to establish its intracellular propagation. To facilitate invasion, the parasites secrete invasion effectors from microneme and rhoptry, two unique organelles in apicomplexan...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
5e4943cb-6d6b-5ee5-ac11-a07811cac17d
DOI
10.1101/2023.01.21.525043
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A cathepsin C-like protease post-translationally modifies <i>Toxoplasma gondii</i> secretory proteins for optimal invasion and egressDOI 10.1101/2023.01.21.525043
Molecular Signals in the Trafficking of <i>Toxoplasma gondii</i> Protein MIC3 to the MicronemesSemantic proximity
A spatially localized rhomboid protease cleaves cell surface adhesins essential for invasion by <i>Toxoplasma</i>Semantic proximity
A cleavable propeptide influences Toxoplasma infection by facilitating the trafficking and secretion of the TgMIC2-M2AP invasion complex.Semantic proximity
Molecular Dissection of Novel Trafficking and Processing of the T oxoplasma gondii Rhoptry Metalloprotease Toxolysin‐1Semantic proximity
An ortholog of <i>P. falciparum</i> chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in <i>Toxoplasma gondii</i> to facilitate host invasionSemantic proximity
Toxoplasma gondii TFP1 is an essential transporter family protein critical for microneme maturation and exocytosisSemantic proximity
Cysteine Protease Inhibitors Block <i>Toxoplasma gondii</i> Microneme Secretion and Cell InvasionSemantic proximity
Fundamental Roles of the Golgi-Associated Toxoplasma Aspartyl Protease, ASP5, at the Host-Parasite InterfaceSemantic proximity
Microneme Rhomboid Protease TgROM1 Is Required for Efficient Intracellular Growth of Toxoplasma gondiiSemantic proximity
Role of GRA41 in Neospora caninum pathogenicity: insights into tachyzoite egress and microneme secretionSemantic proximity
<i>Toxoplasma gondii</i> PPM3C, a secreted protein phosphatase, affects parasitophorous vacuole effector exportSemantic proximity
Biogenesis and secretion of micronemes inToxoplasma gondiiSemantic proximity
Select a neighboring publication to make it the new centre.