Article

Defining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable Biopharmaceuticals

2024-06-19

Abstract excerpt

<h4>Summary</h4> Biopharmaceuticals are the fastest growing class of drugs in the healthcare industry, but their global reach is severely limited by their propensity for rapid aggregation. Currently, surfactant excipients such as polysorbates and poloxamers are used to prevent protein aggregation, which significantly extends shelf-life. Unfortunately, these excipients are themselves unstable, oxidizing rapidly in...

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Literature Corpus work: a49621cd-e01f-5ee9-bb70-8a2631dd90fb
DOI: 10.1101/2024.06.17.599313

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Defining Structure-Function Relationships of Amphiphilic Excipients Enables Rational Design of Ultra-Stable BiopharmaceuticalsDOI 10.1101/2024.06.17.599313Read

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