Article

Structure–Property–Performance Engineering of Hydrogel Depots for Long-Acting Peptide Delivery

2026-05-18

Abstract excerpt

Controlled release systems for subcutaneous peptide delivery often exhibit a pronounced initial burst release followed by inadequate maintenance of therapeutic exposure, limiting depot lifetime and increasing pharmacokinetic variability. Here, we engineer a dynamic, injectable hydrogel depot technology for months-long delivery of lipidated peptides. Using semaglutide as a model, we establish a modular formulation...

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Literature Corpus work: e5f3f650-6134-5804-ab6e-30f97ab3dfbe
DOI: 10.64898/2026.05.17.725768

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