Article

GSK-3β inhibitors can rescue neurons through the prosurvival(autophagy) mechanism in Parkinson’s Disease

2022-04-12

Abstract excerpt

Parkinson’s disease (PD) is a chronic progressive neurodegenerative disorder. The underlying molecular mechanism lead to α-synuclein aggregation, progressive and selective loss of dopaminergic neurons, and intracellular inclusions (known as Lewy bodies (LBs)). Several genetic and environmental factors may lead to PD. Ecological factors can influence the onset of most sporadic PD cases via genetically mediated path...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a48ba2f5-d15d-5f13-9b9f-b7e99fab54f3
DOI: 10.21203/rs.3.rs-1533307/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GSK-3β inhibitors can rescue neurons through the prosurvival(autophagy) mechanism in Parkinson’s DiseaseDOI 10.21203/rs.3.rs-1533307/v1Read

Mechanisms and Therapeutic Implications of GSK-3 in Treating NeurodegenerationSemantic proximity Read

GSK‐3 in Neurodegenerative DiseasesSemantic proximity Read

GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and TideglusibSemantic proximity Read

The Parkinson disease protein α-synuclein inhibits autophagySemantic proximity Read

Lovastatin protects neurite degeneration in LRRK2-G2019S parkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity.Semantic proximity Read

Inhibition of miR-937-3p by targeting SNCB ameliorates rotenone-induced toxicity in SH- SY5Y cells by reducing alpha-synuclein aggregation and apoptosisSemantic proximity Read

Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin–proteasome systemSemantic proximity Read

Autophagy protects the rotenone-induced cell death in alpha-synuclein overexpressing SH-SY5Y cells.Semantic proximity Read

PKB/AKT attenuates Lewy Body-like pathology in primary neurons via Cathepsins B and DSemantic proximity Read

Neuronal PARIS-STAT3 axis drives tau pathology and glial activation in Alzheimer’s diseaseSemantic proximity Read

Parkinsonism Reversal and Dopaminergic Resilience: Lessons from a Rotenone-induced Parkinson’s Disease ModelSemantic proximity Read

Impaired Wnt signaling in dopamine containing neurons is associated with pathogenesis in a rotenone triggered Drosophila Parkinson’s disease modelSemantic proximity Read