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Article

BMPR2 expression is suppressed by signaling through the estrogen receptor

1 Jan 2012

Abstract excerpt

BACKGROUND: Studies in multiple organ systems have shown cross-talk between signaling through the bone morphogenetic protein receptor type 2 (BMPR2) and estrogen pathways. In humans, pulmonary arterial hypertension (PAH) has a female predominance, and is associated with decreased BMPR2 expression. The goal of this study was to determine if estrogens suppress BMPR2 expression. METHODS: A variety of techniques were...

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PMID: 22348410
DOI: 10.1186/2042-6410-3-6

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