Article

Mutant KRAS promotes NF-κB driven CCL20 chemokine expression in pancreatic ductal adenocarcinoma

2026-04-15

Abstract excerpt

<h4>ABSTRACT</h4> The chemokine CCL20 is implicated in inflammation and cancer but has proven challenging to target therapeutically. In this study, we precisely define what cells produce CCL20 in pancreatic inflammation and cancer. Through analysis of single cell RNA data, mutation and copy number signatures, gene methylation, and in vitro studies, we show that CCL20 and other NF-κB driven chemokine production i...

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Literature Corpus work: a47a8c65-ea67-5914-8064-2c787ae14fa8
DOI: 10.64898/2026.04.13.717530

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