Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and Pathogenesis

3 Apr 2025

Abstract excerpt

The open reading frame 3a (ORF3a) is a protein important to the pathogenicity of SARS-CoV-2. The cytoplasmic domain of ORF3a has three canonical tyrosine-based sorting signals (160YNSV163, 211YYQL213, and 233YNKI236), and a previous study has indicated that mutation of the 160YNSV163 motif abrogated plasma membrane expression and inhibited ORF3a-induced apoptosis. Here, we have systematically removed all three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animal Virus Infections Studies
Share to SARS-CoV-2 and COVID-19 Research
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 40284965
DOI: 10.3390/v17040522

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 in Intracellular Trafficking and PathogenesisPMID 40284965Read ↗

The Role of the Tyrosine-Based Sorting Signals of the ORF3a Protein of SARS-CoV-2 on Intracellular Trafficking, Autophagy, and ApoptosisSemantic proximity Read ↗

The Open Reading Frame 3a Protein of Severe Acute Respiratory Syndrome-Associated Coronavirus Promotes Membrane Rearrangement and Cell DeathSemantic proximity Read ↗

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteinsSemantic proximity Read ↗

ORF3a of SARS-CoV-2 promotes lysosomal exocytosis-mediated viral egressSemantic proximity Read ↗

SARS-Coronavirus Open Reading Frame-3a drives multimodal necrotic cell deathSemantic proximity Read ↗

The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteinsSemantic proximity Read ↗

Genetic variety of ORF3a shapes SARS‐CoV‐2 fitness through modulation of lipid dropletSemantic proximity Read ↗

The Severe Acute Respiratory Syndrome (SARS)-coronavirus 3a protein may function as a modulator of the trafficking properties of the spike proteinSemantic proximity Read ↗

Activity and cellular distribution of ORF3a mutants of SARS-CoV-2 variants of concern.Semantic proximity Read ↗

The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-ISemantic proximity Read ↗

Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesisSemantic proximity Read ↗

SARS-CoV-2 accessory proteins ORF7a and ORF3a use distinct mechanisms to downregulate MHC-I surface expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.