Article

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

2022-11-15

Abstract excerpt

<h4>SUMMARY</h4> The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has been confirmed independently by ribosome profiling. Despite ORF3c also being present in the 2002-2003 SARS-CoV, its function has remained unexplored. Here we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a167b340-00a1-5a3f-a049-5fa7e22d4850
DOI: 10.1101/2022.11.15.516323

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunityDOI 10.1101/2022.11.15.516323Read

The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunitySemantic proximity Read

SARS-CoV-2 ORF8: One protein, seemingly one structure, and many functionsSemantic proximity Read

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progressionSemantic proximity Read

Omicron-Enhanced Immunosuppressive Effects of SARS-CoV-2 ORF3a and ORF9b Accessory Proteins on Monocytic Inflammatory ResponseSemantic proximity Read

Middle East respiratory syndrome coronavirus-encoded ORF8b strongly antagonizes IFN-β promoter activation: its implication for vaccine designSemantic proximity Read

SARS-CoV-2 ORF8 modulates lung inflammation and clinical disease progression.Semantic proximity Read

Impairment of antiviral immune response and disruption of cellular functions by SARS-CoV-2 ORF7a and ORF7bSemantic proximity Read

SARS-CoV-2 ORF9c Is a Membrane-Associated Protein that Suppresses Antiviral Responses in CellsSemantic proximity Read

Impact of SARS-CoV-2 ORF6 and its variant polymorphisms on host responses and viral pathogenesisSemantic proximity Read

SARS-CoV-2 Accessory Protein ORF7b Mediates Tumor Necrosis Factor-α-Induced Apoptosis in CellsSemantic proximity Read

SARS-CoV-2 ORF8: A Rapidly Evolving Immune and Viral Modulator in COVID-19Semantic proximity Read

SARS-CoV-2 ORF9b exploits mitochondrial recruitment to TOMM70 for proteasomal protection and tunes inflammatory remodeling during lung infectionSemantic proximity Read