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The SARS-CoV-2 protein ORF3c is a mitochondrial modulator of innate immunity

28 Sept 2023

Abstract excerpt

The SARS-CoV-2 genome encodes a multitude of accessory proteins. Using comparative genomic approaches, an additional accessory protein, ORF3c, has been predicted to be encoded within the ORF3a sgmRNA. Expression of ORF3c during infection has been confirmed independently by ribosome profiling. Despite ORF3c also being present in the 2002-2003 SARS-CoV, its function has remained unexplored. Here we show that ORF3c...

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PMID: 37860693
DOI: 10.1016/j.isci.2023.108080

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