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Article

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.

The Journal of biological chemistry - 3 Jul 2015

Cantlon Adam, Frigerio Carlo Sala, Freir Darragh B, Boland Barry, Jin Ming, Walsh Dominic M

Abstract excerpt

Familial British dementia (FBD) is an inherited neurodegenerative disease believed to result from a mutation in the BRI2 gene. Post-translational processing of wild type BRI2 and FBD-BRI2 result in the production of a 23-residue long Bri peptide and a 34-amino acid long ABri peptide, respectively, and ABri is found deposited in the brains of individuals with FBD. Similarities in the neuropathology and clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25957407
DOI: 10.1074/jbc.M115.652263
PMCID: PMC4505405

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The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.PMID 25957407Read ↗

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