Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease.

doi:10.1042/CS20255642

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Article

Molecular drivers of osteogenesis imperfecta: a cellular and extracellular collagen disease.

Clinical science (London, England : 1979) - 18 Dec 2025

Cotti Silvia, Pérez Franco Wendy, Forlino Antonella

Abstract excerpt

The clinical hallmarks of osteogenesis imperfecta (OI), often referred to as 'brittle-bone disease', are bone fragility and skeletal deformities that are usually accompanied by extra skeletal manifestations. OI is a family of collagen I-related disorders, currently classified into 23 distinct types and 5 OI-like forms, with variable phenotypic severity ranging from mild to lethal. At the molecular level, the...

Topics

Humans
Osteogenesis Imperfecta
Mutation
Collagen Type I
Animals
Extracellular Matrix
Phenotype
Collagen

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PMID: 41410595
DOI: 10.1042/CS20255642
PMCID: PMC12794382

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