Article

Genetic Engineering of Umbilical MSCs Co-Expressing PD-1 and HSV-1-TK for Immune Activation and Tumor Eradication

2026-05-07

Abstract excerpt

<title>Abstract</title> <p>Genetically engineered umbilical mesenchymal stem cells (GE-UMSCs) offer a promising approach for targeted cancer therapy. This study aimed to develop a dual-functional therapeutic platform—UPT—by co-expressing PD-1 and HSV-1-TK in UMSCs to enhance both immune modulation and tumoricidal activity. A non-viral electroporation strategy was used to generate UPT cells. Expression of PD-1 and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a4365565-b178-5269-9df7-1daafc1d50b1
DOI: 10.21203/rs.3.rs-9490147/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic Engineering of Umbilical MSCs Co-Expressing PD-1 and HSV-1-TK for Immune Activation and Tumor EradicationDOI 10.21203/rs.3.rs-9490147/v1Read

Gene Therapy Used in Cancer TreatmentSemantic proximity Read

Safety Evaluation of Long-term Administration of Umbilical Mesenchymal Stem Cell-Derived Extracellular VesiclesSemantic proximity Read

Application and prospects of genetic engineering in CAR-NK cell therapySemantic proximity Read

Concise Review: Genetically Engineered Stem Cell Therapy Targeting Angiogenesis and Tumor Stroma in Gastrointestinal MalignancySemantic proximity Read

Human Adipose-Derived Stem Cells Genetically Programmed to Induce Necroptosis for Cancer ImmunotherapySemantic proximity Read

Non-viral approaches in CAR-NK cell engineering: connecting natural killer cell biology and gene deliverySemantic proximity Read

Targeting uPAR with engineered extracellular vesicles from HEK 293T cells suppresses tumor growth in uPAR positive glioma modelsSemantic proximity Read

Genetically stable multi-gene edited iPSCs-derived NK cells for enhanced cancer immunotherapySemantic proximity Read

Minicircle DNA-Mediated CAR T Cells Targeting CD44 Suppressed Hepatocellular Carcinoma Both in vitro and in vivoSemantic proximity Read

A Multifunctional Delivery System for Remodulating Cell Behaviors of Circulating Malignant Cells to Prevent Cell FusionSemantic proximity Read

Advancements in gene therapy for lung cancer: from genetic insights to clinical applicationsSemantic proximity Read

A comprehensive cancer-associated microRNA expression profiling and proteomic analysis of human umbilical cord mesenchymal stem cell derived exosomes.Semantic proximity Read