Article

Targeting uPAR with engineered extracellular vesicles from HEK 293T cells suppresses tumor growth in uPAR positive glioma models

2026-07-20

Abstract excerpt

<title>Abstract</title> <p>By virtue of inherent biocompatibility and delivery efficiency, extracellular vesicles (EVs) are regarded as a novel and promising drug delivery system (DDS) for disease treatment. In this study, we designed and generated engineered HEK293T cells (HEK919) featuring an inducible Tet-On® 3G system to co-express a uPAR-targeting domain (ATF-uPA), TNF-related apoptosis-inducing ligand(TRAIL...

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Literature Corpus work: 61b9b74a-8dca-5277-958f-5efaea4580e4
DOI: 10.21203/rs.3.rs-10061331/v1

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