Article
An overlapping protein-coding region in influenza A virus segment 3 modulates the host response.
Science (New York, N.Y.) - 13 Jul 2012
Jagger B W, Wise H M, Kash J C, Walters K-A, Wills N M, Xiao Y-L, Dunfee R L, Schwartzman L M, Ozinsky A, Bell G L, Dalton R M, Lo A, Efstathiou S, Atkins J F, Firth A E, Taubenberger J K, Digard P
Abstract excerpt
Influenza A virus (IAV) infection leads to variable and imperfectly understood pathogenicity. We report that segment 3 of the virus contains a second open reading frame ("X-ORF"), accessed via ribosomal frameshifting. The frameshift product, termed PA-X, comprises the endonuclease domain of the viral PA protein with a C-terminal domain encoded by the X-ORF and functions to repress cellular gene expression. PA-X...
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