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Article

Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance.

Cells - 4 Dec 2020

Belisario Dimas Carolina, Kopecka Joanna, Pasino Martina, Akman Muhlis, De Smaele Enrico, Donadelli Massimo, Riganti Chiara

Abstract excerpt

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response increasing the pro-survival and pro-invasive phenotype of cancer cells, and determine a broad metabolic rewiring. These events favor tumor progression and chemoresistance. The increase in glucose and amino acid uptake, glycolytic flux, and lactate...

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Identifiers

PMID: 33291643
DOI: 10.3390/cells9122598
PMCID: PMC7761956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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