Article
Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models.
Scientific reports - 11 Mar 2021
Tosh Justin L, Rhymes Elena R, Mumford Paige, Whittaker Heather T, Pulford Laura J, Noy Sue J, Cleverley Karen, Walker Matthew C, Tybulewicz Victor L J, Wykes Rob C, Fisher Elizabeth M C, Wiseman Frances K
Abstract excerpt
Individuals who have Down syndrome (caused by trisomy of chromosome 21), have a greatly elevated risk of early-onset Alzheimer's disease, in which amyloid-β accumulates in the brain. Amyloid-β is a product of the chromosome 21 gene APP (amyloid precursor protein) and the extra copy or 'dose' of APP is thought to be the cause of this early-onset Alzheimer's disease. However, other chromosome 21 genes likely...
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