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Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk

17 Apr 2019

Abstract excerpt

Three Ebolavirus genus viruses cause lethal disease and lack targeted therapeutics: Ebola virus, Sudan virus and Bundibugyo virus. Monoclonal antibody (mAb) cocktails against the surface glycoprotein (GP) present a potential therapeutic strategy. Here we report two crystal structures of the antibody BDBV223, alone and complexed with its GP2 stalk epitope, an interesting site for therapeutic/vaccine design due to...

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PMID: 30996276
DOI: 10.1038/s41467-019-09732-7

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