Article

Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking

2019-01-08

Abstract excerpt

Despite 50+ years of clinical use as anxiolytics, anti-convulsants, and sedative/hypnotic agents, the mechanisms underlying benzodiazepine (BZD) tolerance are poorly understood. BZDs potentiate the actions of gamma-aminobutyric acid (GABA), the primary inhibitory neurotransmitter in the adult brain, through positive allosteric modulation of γ2 subunit containing GABA type A receptors (GABAARs). Here we define key...

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Literature Corpus work: a3a1aa3d-2d5c-5bd2-8974-974093b4f779
DOI: 10.1101/514133

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