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HIV-PULSE: a long-read sequencing assay for high-throughput near full-length HIV-1 proviral genome characterization

19 Sept 2023

Abstract excerpt

A deep understanding of the composition of the HIV-1 reservoir is necessary for the development of targeted therapies and the evaluation of curative efforts. However, current near full-length (NFL) HIV-1 proviral genome sequencing assays are based on labor-intensive and costly principles of repeated PCRs at limiting dilution, restricting their scalability. To address this, we developed a high-throughput,...

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PMID: 37819007
DOI: 10.1093/nar/gkad790

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