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Article

Cancer-Associated Mutations Reveal a Novel Role for EpCAM as an Inhibitor of Cathepsin-L and Tumor Cell Invasion

2020-12-07

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>Epithelial cell adhesion molecule (EpCAM) is a 40-kD type-I transmembrane protein that is frequently overexpressed in human epithelial cancers. Recent evidence implicates EpCAM in the regulation of oncogenic signaling pathways and epithelial-mesenchymal transition. Of note, multiple proteins with thyroglobulin-type-1 (TY-1) domains are known to inhibit cathepsin-L...

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Literature Corpus work
a398a3fb-7e96-57c7-82d4-5b3fce442acd
DOI
10.21203/rs.3.rs-121096/v1
Open publication

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Cancer-Associated Mutations Reveal a Novel Role for EpCAM as an Inhibitor of Cathepsin-L and Tumor Cell InvasionDOI 10.21203/rs.3.rs-121096/v1
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