Article

Thiosemicarbazone T2 suppresses WNT/β-catenin signaling and limits progression to invasive disease in a mouse intraductal model of triple-negative breast cancer

2026-06-09

Abstract excerpt

<h4>ABSTRACT</h4> T2, an N4-aryl-substituted thiosemicarbazone, has previously been shown to exert cytotoxic and anti-invasive effects in triple-negative breast cancer (TNBC) and to increase expression of the metastasis suppressor N-myc downstream-regulated gene 1 (NDRG1). Given the role of NDRG1 in regulating epithelial–mesenchymal transition (EMT) and WNT/β-catenin signaling, we investigated the contribution of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a38214c6-6e6d-56a5-aee0-839dd86f12c4
DOI: 10.64898/2026.06.05.730419

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Thiosemicarbazone T2 suppresses WNT/β-catenin signaling and limits progression to invasive disease in a mouse intraductal model of triple-negative breast cancerDOI 10.64898/2026.06.05.730419Read

Acetyl-cinobufagin Suppresses Triple Negative Breast Cancer Progression by Inhibiting the STAT3 PathwaySemantic proximity Read

Inhibition of triple negative breast cancer metastasis and invasiveness by novel drugs that target epithelial to mesenchymal transitionSemantic proximity Read

Type-I interferon signaling is essential for robust metronomic chemo-immunogenic tumor regression in murine triple-negative breast cancerSemantic proximity Read

Repurposing mebendazole against triple-negative breast cancer leptomeningeal diseaseSemantic proximity Read

Targeting claudin-4 enhances chemosensitivity of triple negative breast cancerSemantic proximity Read

Sox4 Regulates the Sensitivity of Canine Mammary Gland Tumor Cells to Cisplatin via the Wnt/β-catenin Signaling PathwaySemantic proximity Read

Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancerSemantic proximity Read

Recurrent triple-negative breast cancer from cysteine deprivation loses tumorigenicity via downregulation of the CST4 signalingSemantic proximity Read

Preclinical efficacy of the Wnt/β-catenin pathway inhibitor BC2059 for the treatment of desmoid tumors.Semantic proximity Read

The Rexinoid V-125 Reduces Tumor Growth in Preclinical Models of Breast and Lung CancerSemantic proximity Read

Wnt/β-catenin inhibition disrupts drug-tolerance in isogenic carboplatin-resistant models of Triple-Negative Breast CancerSemantic proximity Read

A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders.Semantic proximity Read