Article

Repurposing mebendazole against triple-negative breast cancer leptomeningeal disease

2024-02-05

Abstract excerpt

<h4>Purpose: </h4> Triple-negative breast cancer (TNBC) is an aggressive subtype that often metastasizes to the brain. Leptomeningeal disease (LMD), a devastating brain metastasis common in TNBC, has limited treatment options. We sought to test whether the common anti-helminthic drug mebendazole (MBZ) may be effective against murine TNBC LMD. Methods A small-molecule screen involving TNBC cell lines identified be...

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Literature Corpus work: de150978-75f7-533b-b665-8bbc46e89ae3
DOI: 10.21203/rs.3.rs-3915392/v1

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