Article

The Rexinoid V-125 Reduces Tumor Growth in Preclinical Models of Breast and Lung Cancer

2021-08-23

Abstract excerpt

Rexinoids are ligands which activate retinoid X receptors (RXRs), regulating transcription of genes involved in cancer-relevant processes. Rexinoids have anti-neoplastic activity in multiple preclinical studies. Bexarotene, used to treat cutaneous T cell lymphoma, is the only FDA-approved rexinoid. Bexarotene has also been evaluated in clinical trials for lung and metastatic breast cancer, wherein subsets of patie...

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Literature Corpus work: d7429b4c-c690-54a3-b879-15aeb1a80a56
DOI: 10.21203/rs.3.rs-826798/v1

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