Article

Targeting claudin-4 enhances chemosensitivity of triple negative breast cancer

2019-08-04

Abstract excerpt

<title>Abstract</title> <p>Background Triple negative breast cancer (TNBC) possesses highly aggressive phenotype, treatment with limited options, and a poor prognosis. In this study, we examined the therapeutic effect of anti-claudin (CLDN)-4 extracellular domain antibody, 4D3, on TNBC. Methods The expression of CLDN4 and CLDN1 in invasive ductal carcinoma (IDC) was examined in 78 IDCs (from 2004 to 2009 in a...

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Literature Corpus work: 4acd7da2-2a54-58fb-abfd-679ca9e3f289
DOI: 10.21203/rs.2.12416/v1

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