Article

Structural Basis of Transcriptional Coactivator PC4 Binding to a Platinum Crosslinked Double-Stranded Oligonucleotide

2026-02-27

Abstract excerpt

<title>Abstract</title> We previously discovered that human nuclear cofactor PC4 selectively binds to a double-stranded oligodeoxynucleotide (dsODN) crosslinked by a <italic>trans</italic> -platinum anticancer complex, <italic>trans</italic> -[PtCl 2 (NH 3 )(thiazole)] ( <italic>trans-</italic> PtTz), which was further demonstrated to reduce its cytotoxicity by mediating DNA r...

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Literature Corpus work: a3809be2-a824-5fb6-92a0-1cb9692a2256
DOI: 10.21203/rs.3.rs-8574332/v1

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