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Article

Pt-based drugs: the spotlight will be on proteins

1 Jan 2014

Abstract excerpt

Platinum-complexes represent some of the most successful groups of clinically used anticancer drugs. Their mechanism of action relies on the formation of stable DNA adducts occurring at the nitrogen in position 7 of guanine (N7) and involving one or two spatially close residues. The formation of stable DNA adducts is recognized as a DNA damaging event and, ultimately, drives cells to death. Nevertheless,...

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PMID: 24510227
DOI: 10.1039/c3mt00357d

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