Article

Genomic characterization of therapy-associated polyposis reveals an alkylating mutational signature from prior treatment

2026-02-22

Abstract excerpt

Gastrointestinal (GI) polyposis is a major risk factor for colorectal cancer (CRC) and a defining feature of hereditary polyposis syndromes such as familial adenomatous polyposis (FAP). Therapy-associated polyposis (TAP), however, is a rare and incompletely characterized condition that develops decades after treatment for childhood or young adult cancers (CYAC), most often following abdominopelvic radiation or exp...

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Literature Corpus work: a36c679e-f86e-54f0-932b-cd2ee3f9dcbe
DOI: 10.64898/2026.02.12.25340205

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