Article
Therapy-associated polyposis as a late sequela of cancer treatment.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association - 1 Jun 2014
Yurgelun Matthew B, Hornick Jason L, Curry Victoriana K, Ukaegbu Chinedu I, Brown Emily K, Hiller Elaine, Chittenden Anu, Goldberg Joel E, Syngal Sapna
Abstract excerpt
Survivors of childhood cancers are at increased risk of developing secondary gastrointestinal cancers, including colorectal cancer, later in life, possibly from exposure to abdominopelvic radiotherapy and/or alkylating chemotherapy. Profuse gastrointestinal polyposis is associated with rare, inherited colorectal cancer predisposition syndromes, most commonly caused by mutations in the adenomatous polyposis coli...
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