Article

Upregulated SEMA3C in astrocytes contributes to Rett Syndrome phenotypes

2025-10-12

Abstract excerpt

<h4>Summary</h4> Astrocytes support neuronal function during development through secreted proteins, yet how astrocyte-secreted cues are altered in disease states and contribute to neurodevelopmental disorders remains poorly defined. Rett syndrome (RTT) is a regressive neurodevelopmental disorder characterized by motor, sensory, and cognitive impairments. Here, we identify the class 3 semaphorin SEMA3C as an astro...

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Literature Corpus work: 2960b6f0-747a-56f0-b6fb-beb9cb83e77e
DOI: 10.1101/2025.10.10.681027

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