Article

A Study of the Potential Anti-Inflammatory Drugs Chalcone Derivatives through the Combination of NMR Spectroscopy and Molecular Modeling

2024-11-04

Abstract excerpt

In this study, 2 chalcone analogues were synthesized and assessed through in silico and experimental methods for their potential to inhibit the lipoxygenase enzyme, which plays a role in the inflammation pathway. The structure elucidation of each chalcone was conducted through a combination of Nuclear Magnetic Resonance (NMR) and Density Functional Theory (DFT). Α “LOX-chalcone” complex, predicte...

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Literature Corpus work: a342adfc-115d-5267-bbe8-13a7c749b429
DOI: 10.20944/preprints202411.0126.v1

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