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An integrative computational approach for the identification of dual inhibitors of isocitrate dehydrogenase 1 and 2 from phytocompounds of Phyllantus amarus.

Journal of biomolecular structure & dynamics - 1 Sept 2024

Bello Ridwan Opeyemi, Okunlola Salihaat Toyin, Kumar Neeraj, Victor Omoboyede, Jimoh Tajudeen O, Abdulsalam Zainab Naeem, Kehinde Idayat Oyinkansola, Umar Haruna Isiyaku

Abstract excerpt

Genetic alterations of the genes encoding the isocitrate dehydrogenase (IDH) enzymes have been identified in about 20% of acute myeloid leukemia (AML) cases as well as many other forms of cancers. Notable among these alterations are the neomorphic IDH1_R132H and IDH2_R140Q mutations which lead to the production of an oncometabolite. Hence, their inhibition is widely considered a therapeutic strategy in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37559488
DOI: 10.1080/07391102.2023.2245494

Genes

IDH1
IDH2

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