Article

Identifying of selective agonists targeting LXRβ from terpene compounds of Alismatis Rhizoma

2021-02-01

Abstract excerpt

Hyperlipidemia is thought as an important contributor to coronary disease, diabetes and fatty liver. Liver X receptors β (LXRβ) was considered as a validated target for hyperlipidemia therapy due to its role in regulating cholesterol homeostasis and immunity. However, many current drugs applied in clinic are not selectively targeting LXRβ and they can also activate LXRα which activate SREBP-1c worked as activator...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba8be4c2-928e-57e9-83e7-faf05720b1c3
DOI: 10.21203/rs.3.rs-164666/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identifying of selective agonists targeting LXRβ from terpene compounds of Alismatis RhizomaDOI 10.21203/rs.3.rs-164666/v1Read

Identification of a Novel Liver X Receptor Agonist that Regulates the Expression of Key Cholesterol Homeostasis Genes with Distinct Pharmacological Characteristics.Semantic proximity Read

Bioactive Glycosylated Flavonoids Exhibiting LXRs Agonist Activity From a Lauraceae Colombian SpecieSemantic proximity Read

Liver-X receptor β-selective agonist CE9A215 regulates Alzheimer’s disease- associated pathology in a 3xTg-AD mouse modelSemantic proximity Read

Computational prediction of gamma-oryzanol as potential agonist of human peroxisome proliferator-activated receptor gamma (ppar-γ)Semantic proximity Read

Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular DiseasesSemantic proximity Read

Integrative analysis of Myrcene’s lipase inhibition and anti-inflammatory mechanisms in human monocytic cellsSemantic proximity Read

Primulagenin A is a potent inverse agonist of the nuclear receptor RAR-related orphan receptor gamma (RORγ)Semantic proximity Read

Structural Basis of Novel Bile Acid-Based Modulators of FXRSemantic proximity Read

Sterols from Cyathea Bicrenata Liebm Rhizome and their Breast Cancer Activity in vitro and in silico EvaluationSemantic proximity Read

TXN, a Xanthohumol Derivative, Attenuates High-Fat Diet Induced Hepatic Steatosis by Antagonizing PPARγSemantic proximity Read

Revealing Edible Bird Nest as Novel Functional Foods in Combating Metabolic Syndrome: Comprehensive In Silico, In Vitro, and In Vivo StudiesSemantic proximity Read

Molecular Insights and Therapeutic Potential of Lekhaniya Mahakashaya (LM): A Network Pharmacology Approach for ObesitySemantic proximity Read