Article

Nine steps to proteomic wisdom: A practical guide to using protein-protein interaction networks and molecular pathways as a framework for interpreting disease proteomic profiles.

2007-09-01

Abstract excerpt

A major aim of proteomic profiling of disease is to uncover the mechanistic basis of a given pathology. High-throughput experimental techniques continue to advance rapidly, but are still plagued by high rates of false negatives, false positives, and other spurious findings. By reducing a disease profile to a subset of differentially expressed proteins and determining functional over-representation, one can often m...

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Literature Corpus work: a2dc287d-5453-5811-ac19-91f60d978dea
DOI: 10.1002/prca.200700146

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