Article

ARP2/3 complex mediates the neuropathology of PTEN-deficient human neural cells downstream of mTORC1 and mTORC2 hyperactivation

2025-08-27

Abstract excerpt

<h4>Summary</h4> Mutations in the phosphatase and tensin homolog ( PTEN ) gene are linked to severe neurodevelopmental disorders. Loss of PTEN causes hyperactivation of both mechanistic target of rapamycin (mTOR) complexes, mTORC1 and mTORC2. Recent studies have shown that this dual hyperactivation is required for the neuropathology observed in PTEN -deficient human stem cell-derived neural cells. However, the...

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Literature Corpus work: a2d8f8f1-e098-57cf-b2f0-0060421764fb
DOI: 10.1101/2025.08.22.670964

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