Back to search

Article

Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patients

2025-10-20

Abstract excerpt

<title>Abstract</title> <p>Metastatic breast cancer (MBC) is generally an incurable neoplasm. A small cohort of patients with HER2-positive MBC, however, achieve such prolonged remission without relapse following anti-HER2 therapy and chemotherapy, that it is speculated they might be cured. The genomes of these patients might provide insights into the underlying mechanisms for their successful treatment. Here, a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
a2d77fb9-8045-59f4-9af6-5c88266b4c94
DOI
10.21203/rs.3.rs-7761791/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Chromosome centromere copy number amplification associated with exceptional response in HER2-positive metastatic breast cancer patientsDOI 10.21203/rs.3.rs-7761791/v1
Genomic landscape of extraordinary responses in metastatic breast cancer.Semantic proximity
Significance of centromere protein genes and their associated immune and metabolic differences in the prediction of prognosis and treatment outcome in breast cancerSemantic proximity
LncRNA MBNL1-AS1 Represses Proliferation and Cancer Stem-Like Properties of Breast Cancer Through MBNL1-AS1/ZFP36/CENPA AxisSemantic proximity
Minimal Residual Disease via circulating tumor DNA Predicts Exceptional Response in HER2-Positive Metastatic Breast CancerSemantic proximity
Elevated expression of the centromere protein-A(CENP-A)-encoding gene as a prognostic and predictive biomarker in human cancers.Semantic proximity
High tumor copy number variations burden was associated with poor prognosis in patients with endocrine-resistant breast cancerSemantic proximity
Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumorsSemantic proximity
Activated interferon signaling by down-regulation of CENP-N contributing to inhibited tumor growth in breast cancerSemantic proximity
Total whole-arm chromosome losses predict malignancy in human cancerSemantic proximity
Upregulation of centromere protein M promotes tumorigenesis: A potential predictive target for cancer in humans.Semantic proximity
Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer.Semantic proximity
Prognostic significance of centromere 17 copy number gain in breast cancer depends on breast cancer subtype.Semantic proximity
Select a neighboring publication to make it the new centre.