Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer.

doi:10.1158/1055-9965.EPI-11-0343

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Article

Relationship of extreme chromosomal instability with long-term survival in a retrospective analysis of primary breast cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2011

Roylance Rebecca, Endesfelder David, Gorman Patricia, Burrell Rebecca A, Sander Jil, Tomlinson Ian, Hanby Andrew M, Speirs Valerie, Richardson Andrea L, Birkbak Nicolai J, Eklund Aron C, Downward Julian, Kschischo Maik, Szallasi Zoltan, Swanton Charles

Abstract excerpt

BACKGROUND: Chromosomal instability (CIN) is thought to be associated with poor prognosis in solid tumors; however, evidence from preclinical and mouse tumor models suggest that CIN may paradoxically enhance or impair cancer cell fitness. Breast cancer prognostic expression signature sets, which reflect tumor CIN status, efficiently delineate outcome in estrogen receptor ER-positive breast cancer in contrast to...

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PMID: 21784954
DOI: 10.1158/1055-9965.EPI-11-0343
PMCID: PMC3199437

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