Article

LRRK2 and Rab10 Coordinate Macropinocytosis to Mediate Immunological Responses in Phagocytes

2020-01-31

Abstract excerpt

Genetic variation in LRRK2 associates with susceptibility to Parkinson’s disease, Crohn’s disease, and mycobacteria infection, with high expression of LRRK2, and the LRRK2 kinase substrate Rab10, in phagocytic cells in the immune system. In mouse and human primary monocyte-derived macrophages, dendritic cells, and microglia-like cells, we find that Rab10 specifically regulates a specialized form of endocytosis kn...

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Literature Corpus work: a2b9b644-f11b-5876-b244-1cdf2016ecaa
DOI: 10.1101/2020.01.30.926840

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