Article

A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease

2025-09-20

Abstract excerpt

Polycystic kidney disease (PKD) arises from mutations in cilia-associated genes, such as PKD1 and PKD2 , expressed in renal epithelial cells, leading to progressive kidney dysfunction and end- stage kidney disease (ESKD). PKD patients exhibit significant heterogeneity in disease progression, largely due to genetic and environmental modifiers. Like patients, mouse models of PKD also exhibit significant heterogene...

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Literature Corpus work: a2a419eb-ba4c-509b-aee8-7447a098b7af
DOI: 10.1101/2025.09.17.676846

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