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The bromodomain protein BRD4 regulates the KEAP1/NRF2-dependent oxidative stress response

24 Apr 2014

Abstract excerpt

The epigenetic sensor BRD4 (bromodomain protein 4) is a potent target for anti-cancer therapies. To study the transcriptional impact of BRD4 in cancer, we generated an expression signature of BRD4 knockdown cells and found oxidative stress response genes significantly enriched. We integrated the RNA-Seq results with DNA-binding sites of BRD4 generated by chromatin immunoprecipitations, correlated these with gene...

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PMID: 24763052
DOI: 10.1038/cddis.2014.157

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