Article

Excess Met1-ubiquitination leads to solid aggregate formation

2026-01-20

Abstract excerpt

The ubiquitin ligase HOIL-1 has a unique role in controlling quantity of Met1-linked/ linear ubiquitin chains in cells by coordinating action with the ubiquitin ligase HOIP. Both ligases are components of the Linear UBiquitin chain Assembly Complex (LUBAC), the only known ligase complex that is able to generate Met1-linked ubiquitin chains. Although importance of Met1-linked ubiquitin chains in inflammation and im...

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Literature Corpus work: a27c49d4-aa3a-57bf-bf42-18c23ee0ca66
DOI: 10.64898/2026.01.20.700516

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