Article

Cyclodextrin triggers MCOLN1-dependent endo-lysosome secretion in Niemann-Pick type C cells

2018-08-27

Abstract excerpt

<h4>ABSTRACT</h4> In specialized cell types, lysosome-related organelles support regulated secretory pathways, while in non-specialized cells, lysosomes can undergo fusion with the plasma membrane in response to a transient rise in cytosolic calcium. Recent evidence also indicates that lysosome secretion can be controlled transcriptionally and promote clearance in lysosome storage diseases. In addition, evidence...

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Literature Corpus work: a27842a6-f9de-5375-bd2d-76fd585717af
DOI: 10.1101/401190

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