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Article

Cyclodextrin Induces Calcium-Dependent Lysosomal Exocytosis

29 Nov 2010

Abstract excerpt

Cyclodextrins (CDs) have long been used to manipulate cellular cholesterol levels both in vitro and in vivo, but their direct effects at a cellular level are not well characterized. Recently, CDs have garnered much interest because of their ability to clear stored cholesterol from Niemann Pick Type C (NPC) cells and markedly prolong the life of NPC1 disease mice. Here, we investigate the hypothesis that treatment...

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Share to Calcium signaling and nucleotide metabolism
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Share to Lysosomal Storage Disorders Research

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PMID: 21124786
DOI: 10.1371/journal.pone.0015054

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