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DNA methylome profiling of circulating tumor cells in lung cancer at single base-pair resolution

9 Feb 2021

Abstract excerpt

DNA methylation plays a pivotal role in regulating cellular processes, and altered DNA methylation pattern is a general hallmark of cancer. However, DNA methylome in circulating tumor cells (CTCs) is still a mystery due to the lack of proper analytical techniques. We introduced an efficient workflow, LCM-µWGBS, which can efficiently profile the DNA methylation of microdissected CTC samples. LCM-µWGBS combines the...

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PMID: 33564067
DOI: 10.1038/s41388-021-01657-0

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