Article

A cerebrospinal fluid proteomic clock reveals opposing brain-aging programs and predicts neurological disease progression

2026-07-01

Abstract excerpt

Aging is the risk factor for neurological disease, yet the molecular architecture of human brain aging remains poorly defined. Here, we analyzed more than 10,000 cerebrospinal fluid (CSF) proteomes across multiple cohorts and proteomic platforms to developed a 249-protein CSF aging clock that accurately predicts age and generalizes across independent datasets. CSF brain-age acceleration was increased across divers...

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Literature Corpus work: a23c55a9-af4b-5087-ac5d-2a764672bcc8
DOI: 10.64898/2026.06.26.734784

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