Article

RNA silencing of GM-CSF in CAR-T cells reduces the secretion of multiple inflammatory cytokines

2023-01-05

Abstract excerpt

Chimeric antigen receptor T (CAR-T) cell therapy has become a research hotspot in the field of hematological malignancies. However, CAR-T cell therapy can lead to immunotherapy-associated side effects including cytokine release syndrome and neurotoxicity. Gene depletion of GM-CSF in CAR-T cells was found preventive against adverse effects, but additional transfections were required to produce CAR-T cells. In this...

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Literature Corpus work: 61f60e39-a9b2-5bed-937d-eeaf855278d3
DOI: 10.21203/rs.3.rs-2429383/v1

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