Article

Age-related STAT3 signaling regulates severity of respiratory syncytial viral infection in human bronchial epithelial cells

2023-09-21

Abstract excerpt

<h4>SUMMARY</h4> Respiratory syncytial virus (RSV) can cause severe disease especially in infants; however, mechanisms of age-associated disease severity remain elusive. Here, employing human bronchial epithelium models generated from tracheal aspirate-derived basal stem cells of neonates and adults, we investigated whether age regulates RSV-epithelium interaction to determine disease severity. We show that follo...

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Literature Corpus work: a20e5de6-26b2-55fe-84fe-bc5ccb7498e0
DOI: 10.1101/2023.09.20.558606

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